IFN gamma-induced Immunosuppression in Lung Carcinoma is Mediated by an Environmental Chemical Receptor (AhR) through PD-L1 and IDO Control
including Muzamil Khan
July, 2024
Abstract
Aryl hydrocarbon receptor (AhR) known to be immunosuppressive in nature, was knocked out using CRISPR/Cas9 in murine models of lung carcinoma and single-cell RNA sequencing was performed to reveal AhR’s immunosuppression cell programs.